Saint Charles Vacations from $388

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Your Saint Charles Vacation

With a vacation package to Saint Charles, say goodbye to travel planning and hello to stress-free adventure. Every detail of your journey has been taken care of before departing, so you can get on with experiencing this exciting city. Imes Bridge is one of the famous attractions to check off your to-do list during a trip to Saint Charles. Whoever you're traveling with and whatever you want to spend, your ultimate Saint Charles vacation is only clicks away with Expedia.

The Latest Saint Charles vacation packages

Price found within the past 48 hours. Click for updated prices.
AmericInn by Wyndham Ankeny/Des Moines

AmericInn by Wyndham Ankeny/Des Moines

3 out of 5
Price was $450, price is now $388 per person
$388
per person
Jan 28 - Jan 31
found 1 day ago
Roundtrip non-stop flight included
Amarillo (AMA) to Des Moines (DSM)
8/10 Very Good! (818 reviews)
The room was nice. Staff was very pleasant.

Reviewed on Nov 23, 2025

Cobblestone Inn & Suites - Winterset, IA

Cobblestone Inn & Suites - Winterset, IA

2.5 out of 5
Price was $490, price is now $398 per person
$398
per person
Jan 28 - Jan 31
found 1 day ago
Roundtrip non-stop flight included
Amarillo (AMA) to Des Moines (DSM)
9.2/10 Wonderful! (708 reviews)
We found a bug on our bed, it bite Russ.

Reviewed on Nov 5, 2025

My Place Hotel - Ankeny/ Des Moines, IA

My Place Hotel - Ankeny/ Des Moines, IA

3 out of 5
Price was $448, price is now $394 per person
$394
per person
Jan 28 - Jan 31
found 1 day ago
Roundtrip non-stop flight included
Amarillo (AMA) to Des Moines (DSM)
9/10 Wonderful! (758 reviews)
Very clean, quiet, and great staff!

Reviewed on Dec 15, 2025

Qube Hotel

Qube Hotel

2.5 out of 5
Price was $473, price is now $422 per person
$422
per person
Jan 28 - Jan 31
found 1 day ago
Roundtrip non-stop flight included
Amarillo (AMA) to Des Moines (DSM)
8.4/10 Very Good! (726 reviews)
Great staff! Enjoyed our stay.

Reviewed on Dec 3, 2025

Comfort Inn & Suites Ankeny - Des Moines

Comfort Inn & Suites Ankeny - Des Moines

2.5 out of 5
Price was $463, price is now $416 per person
$416
per person
Jan 28 - Jan 31
found 1 day ago
Roundtrip non-stop flight included
Amarillo (AMA) to Des Moines (DSM)
8.8/10 Excellent! (708 reviews)
Slept well. Comfortable beds and great room

Reviewed on Dec 1, 2025

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Saint Charles Hotel Deals

Fairfield Inn and Suites by Marriott Des Moines West

Fairfield Inn and Suites by Marriott Des Moines West

2.5 out of 5
7225 Vista Dr West Des Moines IA
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $98 total per night from Dec 21 to Dec 22
$98 total
Dec 21 - Dec 22
Total with taxes and fees
9/10 Wonderful! (1,000 reviews)
Passing through on way to Michigan from Colorado. Convenient location, excellent service, comfortable room, good breakfast.

Reviewed on Dec 11, 2025

Fairfield Inn and Suites by Marriott Des Moines West
Hotel Fort Des Moines, Curio Collection by Hilton

Hotel Fort Des Moines, Curio Collection by Hilton

4.5 out of 5
1000 Walnut St Des Moines IA
Fully refundableReserve now, pay when you stay
$143 nightly
The price is $160 total per night from Jan 4 to Jan 5
$160 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
9.4/10 Exceptional! (1,066 reviews)
Comfy and stylish lobby and rooms, delicious cafe

Reviewed on Dec 13, 2025

Hotel Fort Des Moines, Curio Collection by Hilton
Home2 Suites by Hilton Des Moines at Drake University

Home2 Suites by Hilton Des Moines at Drake University

3 out of 5
2650 University Ave. Des Moines IA
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $100 total per night from Dec 21 to Dec 22
$100 total
Dec 21 - Dec 22
Total with taxes and fees
9.2/10 Wonderful! (1,003 reviews)
Clean room

Reviewed on Dec 14, 2025

Home2 Suites by Hilton Des Moines at Drake University
See all 621 properties in Saint Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Saint Charles Vacation Packages

Saint Charles Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Des Moines Intl. Airport (DSM)
Population
650
Top Sights
Lake Ahquabi State Park, The Winterset Stage and Holliwell Bridge

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Frequently asked questions

How much does a Saint Charles vacation package cost?
Offering excellent value package deals from $388 on Expedia, you'll be surprised at how little a vacation to Saint Charles costs! Expedia's packages make travel planning easier and your savings go further.
What are the cheapest months to go to Saint Charles?
If you're looking to book a cheap Saint Charles vacation package, consider traveling in November, December and January. You'll generally find better rates on flights and accommodations during these months — ideal for budget-conscious travelers.
How many days is enough for Saint Charles?
The ideal length for your Saint Charles vacation depends on what you'd like to do and see. Typically, a few days to a week will give you enough time to visit all the main attractions and explore some hidden treasures along the way.
How to find the best Saint Charles package deals?
Bagging a cheap Saint Charles package deal is a cinch with Expedia. Once you've entered your destination and trip dates under our "Packages" tab, set your maximum budget, apply some filters and browse what's available. You can customize your search by "Amenities," "Property type," "Guest rating" and more. Order the results by "Price: low to high" to view the most affordable Saint Charles package deals. Want a simple trick to score even more savings? Be flexible with your departure dates and consider traveling on a weekday, when prices are generally lower.
Is it cheaper to book a Saint Charles vacation as a package?
An Expedia vacation package could land you great savings when compared to booking flights and accommodations separately. Better still, you can customize your Saint Charles getaway to fit your exact style. Choose your preferred flight time, select the hotel type and add a rental car. Browse our great deals to see how much you can save.
When to book a vacation package to Saint Charles?
If you're planning an impromptu Saint Charles trip, check out our last-minute deals that can be booked up to a week before you go. Prefer not to wait until the last minute? You can score amazing deals on your hotels and flights by booking ahead.
Does Expedia offer Book Now, Pay Later Saint Charles vacation packages?
Secure your perfect escape to Saint Charles with help from Expedia's Book Now, Pay Later vacations. There's no need to scrimp and save or wait until payday — we've joined forces with online lender Affirm to give you more flexibility and choice. Our vacation packages with payment plans allow you to spread the total cost over 3, 6 or 12 months. With no hidden or late payment fees, you can easily stick to your budget and snap up cheap deals while they last.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.